New York Structural Biology Center
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Mission
The New York Structural Biology Center (NYSBC) is a state-of-the-art research center being developed cooperatively by ten outstanding research centers. The Center houses the largest and most advanced cluster of high-field research NMRs in the Atlantic Hemisphere. A state-of-the-art cryo Electron Microscope facility and sample preparation resources are available. NYSBC is the organizer for the Participating Research Team at beam lines X4A and X4C at Brookhaven National Laboratory. Research conducted at the Center will significantly increase our understanding of the role that proteins play in disease pathways and enhance the ability of scientists to carry out advanced biomedical research in a number of areas including the new fields of structural genomics, and proteomics. NYSBC is bringing together a nexus of scientific talent to generate the sort of collaborative creative community that spawns new technologies and sparks new discoveries.Participants
The New York Structural Biology Center is a 501 (c) (3) corporation incorporated in the State of New York. The corporation is governed by a Board representing ten institutional members. The institutional members are: Albert Einstein College of Medicine of Yeshiva University , City University of New York , Columbia University , Memorial Sloan-Kettering Cancer Center , Mount Sinai School of Medicine , New York University , The Rockefeller University , Wadsworth Center of the Department of Health , the Joan and Sanford Weill Medical College of Cornell University , and the State University of New York . Faculty, postdocs, and students of the Member Institutions can become affiliates of the Center, and details are at the Center's intranet. The Center supports the work of more than 60 laboratories within these institutions. The momentum created by the New York Structural Biology Center has been fueled by an exceptional core group of scientists from the participating institutions who have taken an active role in the Center's development since its inception. The group has been expanded to include other scientists from throughout the area to develop plans for collaborative research projects and future expansion of the facility.Location
The New York Structural Biology Center is located in its own building leased from CUNY adjacent to the City College campus of the City University of New York at Convent Avenue and 133rd Street. The facility includes a 22,000 square foot newly renovated building housing the high-field magnets and a phase II area of more than 12,000 square foot addition built to accommodate additional magnets, laboratories, computers, other new initiatives, and office and classroom space. This has been built with funds from NIH and the City of New York. A third building, predominantly for cryo electron microscopy, has been completed supported by funds from NYSTAR and NIH.Implementation
Active at 1 Aug 2008
Beam Line
- NSLS X-4A for macromolecular crystallography, multi wavelength anomalous diffraction
- NSLS X-4C for macromolecular crystallography, multi wavelength anomalous diffraction
Cryo Electron Microscopy
- 200 kV cryo electron microscope with FEG (FEI)
- 200 kV cryo electron microscope (JEOL) with FEG
- 300 kV cryo electron microscope (JEOL) with FEG
- 120 kv cryo electron microscope (JEOL)
- For CEM, vacuum evaporator, rapid freezing apparatus, cryo substitution control high pressure freezing device, optical diffractometer, film densitometer.
NMR
- 900 MHz four channel NMR system (Bruker) + cryoprobe (TCI)
- 900 MHz US2 four channel NMR system + cryopoprobe (TCI) + CP-MAS
- 800 MHz US2 four channel NMR system (Bruker) + cryoprobe (TCI)
- 800 MHz four channel NMR system (Bruker) + cryoprobe (TCI)
- 800 MHz US2 four channel NMR system + cryoprobe (TXI)
- 750 MHz 89 mm bore four channel solids NMR system (Bruker) with multiple CP-MAS and HR-MAS probes
- 500 MHz four channel NMR system (Bruker) with cryoprobe
- 600 MHz four channel NMR system (Bruker) with cryoprobe
- 700 MHz four channel NMR system (Bruker) with cryoprobe
Other
- 64 node cluster computer system with 128 Gb physical memory
Achievements
- The Center hosts the NIGMS-PSI New York Consortium of Membrane Protein Structure (NYCOMPS).
- The Center has contributed to more than 250 publications from 2002 through Apr 2008.
Contact
To learn more about the Structural Biology Center please contact NYSBC at +1 212 939 0660, email office -AT- nysbc.org . NYSBC is not a degree granting institution. For graduate studies, apply to the Member Institutions listed above, or ask the affiliated Principal Investigators. Faculty, postdocs and students of the Member Institutions are encouraged to look further at the NYSBC intranet. For a directory, please click here. The mail address of the Center is 89 Convent AvenueNew York, New York, 10027-7556, USA
There's a link for more details about getting to the Center.
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