New York Consortium on Membrane Protein Structure (NYCOMPS), funded by the National Institutes of Healthis one of six specialized centers in the protein production phase of the Protein Structure Initiative (PSI).

The center’s goal is to speed structure determination for membrane proteins, starting with bioinformatics analysis of sequence. The investigators also address bottlenecks in the expression, purification, and structure determination of membrane proteins. The center uses automated cloning and expression, high-throughput expression screening, detergents to help solubilize folded proteins, and large-scale purification and labeling of proteins for NMR and X-ray crystallography. Proteins are expressed in insect and mammalian cells as well as E. coli. For more information on NYCOMPS please visit the website. For more on PSI, please visit the NIH's PSI website to read the Mission Statement.

Lab Members

Principal Investigator
Wayne Hendrickson

Head of Research
James Love

Senior Research Associates
Renato Bruni
Brian Kloss

Research Associate
Brandan Hillerich

Technicians
Arriane Morrison
Patricia Rodriguez

Co-Investigators

Albert Einstein College of Medicine
Mark Girvin

Columbia University
Barry Honig
John Hunt
Ann McDermott
Burkhard Rost
Lawrence Shapiro
Ming Zhou

New York University
Da-Neng Wang

The Rockefeller University
Roderick MacKinnon

State Univerity of New York, Buffalo
Thomas Szyperski

Rutgers, The State University of New Jersey
Gaetano Montelione

Oregon Health and Science University
Eric Gouaux

University of Medicine and Dentistry of New Jersey
Masayori Inouye
Nancy Woychik