Research Technician

A Research Technician position is available immediately in the Laboratory of Cell Biophysics at NYSBC. Our project involves developing methodology for a high-throughput screen to identify conditions for crystallizing membrane proteins for analysis by cryoelectron microscopy. This project is part of the NIH Protein Structure Initiative and piggy-backs off of the robotic cloning and expression activities at the New York Consortium on Membrane Protein Structure (NYCOMPS), which is also housed at NYSBC. The position will require skills in biochemistry and in electron microscopy. Although specific experience is preferred, general experience protein chemistry or biophysics will suffice. Send c.v. and names of three references to David Stokes at stokes@nysbc.org.

Not currently seeking ...

Postdoctoral Associates: EM

Positions are currently filled. If you are interested in being considered for future vacancies for postdoctoral associates to work in the Laboratory of Cell Biophysics at the Center, please submit a biographical sketch, a general statement of interest, and the names of three or more references to stokes@nysbc.org.

The Laboratory of Cell Biophysics is studying in the structural basis for cellular adhesion, which is mediated by two types of intercellular junctions: desmosomes and adherens junctions. Although the molecular constituents have been identified and some of their atomic structures identified by x-ray crystallography, their organization in an intact junction is largely unknown. We are employing the technique of electron tomography to study the structure of junctions in situ. Our first application has been on desmosomes, for which we have revealed the packing of cadherin molecules within the intercellular space (see He et al. Science 302:109 2003). We are currently applying these methods to frozen-hydrated preparations in order to evaluate the structure of these macromolecular complexes in a near-native state.

NMR Spectroscopists

Positions are currently filled. If you are interested in having your biographical sketch on file with us, please submit a biographical sketch, a general statement of interest, and the names of three or more references to mailto:office@nysbc.org

The New York Structural Biology Center (NYSBC) is a state-of-the-art research center being developed cooperatively by nine outstanding research centers. The Center will house the largest and most advanced cluster of high-field research magnets (NMRs) in the Americas in its first phase.

The momentum created by the New York Structural Biology Center has been fueled by an exceptional core group of scientists from the participating institutions who have taken an active role in the Center's development since its inception. The group has been expanded to include other scientists from throughout the area to develop plans for collaborative research projects and future expansion of the facility.

Postdoctoral Associates: NMR

Positions are currently filled. If you are interested in being considered for future vacancies for postdoctoral associates to work in the Laboratory of Physical Biochemistry at the Center, please submit a biographical sketch, a general statement of interest, and the names of three or more references to mailto:office@nysbc.org .The research projects in progress include:

• Structures of signal transduction domains and protein kinases
• Use of NMR relaxation methods for orientation and dynamics analysis
• Structures and ligands to apoptosis related proteins
• Applications of segmental isotopic labeling Longer term research aims also
  include :
• High throughput structure determination
• Structures and dynamics of multidomain systems
• Functional mapping by library of small molecules

Candidates should be experienced in one or more of the areas: protein expression systems, NMR structure determination, NMR dynamics studies, or advanced NMR technologies.Please send a biographical sketch with the names of three references to dcadmin@nysbc.org

URL: http://www.nysbc.org